Self-DNA Sensing in Lung Inflammatory Diseases
نویسندگان
چکیده
منابع مشابه
Inflammatory bowel diseases, chronic liver diseases and the lung.
This review is devoted to the distinct associations of inflammatory bowel diseases (IBD) and chronic liver disorders with chronic airway diseases, namely chronic obstructive pulmonary disease and bronchial asthma, and other chronic respiratory disorders in the adult population. While there is strong evidence for the association of chronic airway diseases with IBD, the data are much weaker for t...
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We are very interested in the extensive research by Vernooy et al,1 who addressed the importance of matrix metalloproteases (MMPs) in the pathogenesis and/or the development of COPD. It is likely to be important to evaluate the activity of the proteases rather than the expression of MMPs. Protease/antiprotease imbalance has also been postulated to be important in the pathogenesis of COPD. Howev...
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Apoptosis is an important contributor to the pathophysiology of lung diseases such as acute lung injury (ALI) and chronic obstructive pulmonary disease (COPD). Furthermore, the cellular environment of these acute and chronic lung diseases favors the delayed clearance of apoptotic cells. This dysfunctional efferocytosis predisposes to the release of endogenous ligands from dying cells. These so-...
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Inflammatory lung diseases are characterised by increased expression of multiple inflammatory genes that are regulated by proinflammatory transcription factors, such as nuclear factor-kappa B. Gene expression is regulated by acetylation of core histones through the action of coactivators, such as CREB-binding protein, with intrinsic histone acetyltransferase (HAT) activity. Conversely, gene rep...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2019
ISSN: 1471-4906
DOI: 10.1016/j.it.2019.06.001